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Daughters et al. (2009) presented evidence that the expanded CTG repeat in the ATXN8OS gene is transcribed into an mRNA by having an expanded CUG repeat, conferring a toxic achieve of operate that plays a job inside the SCA8 phenotype. In Mind tissue from humans and mice with SCA8, ATXN8OS mRNA containing the expanded repeat was observed to accumul

Additionally, Rapamycin was demonstrated to attenuate heterotopic ossification in FOP mouse models [sixty six], plus a Section II scientific trial for Rapamycin is currently ongoing. In summary, fast, and remarkable improvements are actually built within our understating of FOP mechanism and drug development. Many potential medicines are presently